How MergeAlign combines alignments

Static MergeAlign image

Suppose we have two sequences, A (a1 a2 a3 a4 a5 a6) and B (b1 b2 b3 b4 b5 b6), and we have aligned them in five different ways. How does MergeAlign find the consensus alignment that maximally represents these five constituent alignments?


If you use MergeAlign please cite:

1. Collingridge PW & Kelly S (BMC Bioinformatics 2012, 13:117)
MergeAlign: improving multiple sequence alignment performance by dynamic reconstruction of consensus multiple sequence alignments.